This is a massive bugaboo in the audio industry in my opinion.
I have always been a PCI soundcard user - and still am to this day, but industry trends are stopping this. I think a big part of this is due to laptops/ipads and the like becoming more popular devices, as well as from a useability standpoint - companies optimise for succesful adoption into a users system - than technical specifications.
I started my DAW with a Terratec soundcard with midi + stereo audio ins and outs roughly 20 years ago.
Fastforward 7 years - i bought an early USB interface - the NI Audio Kontrol 1 to use with a laptop. I could run everything on it - take it out and about - cool!!
Fastworward another few years - and i got more serious about audio and bought a Lynx PCIe AES card (now without midi) - to use with an Apogee Rosetta 800 (8 in / 8 out). Now we're getting there. But - not an all in one solution.
In 2022 - surprisingly - the only (?) companies doing full PCIe audio solutions are Lynx and RME. In a fresh session in FL Studio or Ableton - with a sample buffer rate of 64 (the lowest) i enjoy latency of 0.72m/s. This cant be beaten by USB. However - that's not a deal breaker for most people sadly.
It greatly saddens me that audio in general is a second class citizen with regards to tech advancement. It still blows my mind that the Atari STE with MIDI in built onto its circuit still thwarts the tightness in the midi department - of a brand new full specced blazing machine. We need more development for Realtime O/S in the midi world.