I moved over to Thunderbolt plus Audio over Ethernet. This is where the growth is (Dante etc) in the high end. I think I have 60 channels of IO and thinking of adding another 40.

USB is good enough for a lot of people, though I am not a fan so that covers the average prosumer.

MIDI is a totally different subject, but I can run MIDI clock from audio which is as tight as it gets these days. See USAMO from Expert Sleepers.