The review shows: 1) 5G lower frequencies (700 and 3 600 MHz): a) limited evidence of carcinogenicity in epidemiological studies; b) sufficient evidence of carcinogenicity in experimental bioassays; c) sufficient evidence ofreproductive/developmental adverse effects in humans; d) sufficient evidence of reproductive/ developmental adverse effects in experimental animals; 2) 5G higher frequencies (24.25-27.5 GHz): the systematic review found no adequate studies either in humans or in experimental animals. Conclusions: 1) cancer: FR1 (450 to 6 000 MHz): EMF are probably carcinogenic for humans, in particular related to gliomas and acoustic neuromas; FR2 (24 to 100 GHz): no adequate studies were performed on the higher frequencies; 2) reproductive developmental effects: FR1 (450 to 6 000 MHz): these frequencies clearly affect male fertility and possibly female fertility too. They may have possible adverse effects on the development of embryos, foetuses and newborns; FR2 (24 to 100 GHz): no adequate studies were performed on non-thermal effects of the higher frequencies.