We constantly mess up the ecosystem, merely by introducing existing species into environments which cannot handle them.
Soon we will be able to engineer exotic forms of life, yet we cannot currently control, reign in, or manage current, naturly evolved forms of life.
For example, we have to spray deadly chemicals on crops, to kill fungus, bacteria, etc. Of we have a pest problem, we have to entice them to eat poison, or trick them into traps.
Our control of existing orgamisims is essentially non-existent. The above methods just reduce population, often very ineffectively.
This means that almost certainly, when things we create end up free, we will be incapable of removing them from the ecosystem.
We could literally destroy the biosphere more readily than nukes, or global warming ever could.
And things will get free.