So, uh, what does this provide over Glade, wxGlade, and QtDesigner? Why should I go with this instead of the open-source solution?
(If there's such a set of things for python desktop apps, including a byte code obfuscator ideally, or someone builds it, that'd be awesome and I'd love to know about it!)
There is no such thing as bytecode obfuscation for Python. The nature of Python's bytecode is such that there is no effective way to obfuscate what the bytecode is doing without incurring massive slowdowns. Consider using legal means, rather than technical means, to protect your code from prying eyes, and remember that many proprietary companies publish Python source with their non-free software. My favorite example remains Civilization 4.