Unfortunately the BCR and TCR spatial conformations that govern antigen binding affinity are a result of somatic recombination [1]. The genes edit themselves at runtime to fit their target better. It's stochastic hill climbing happening within us while we're alive.
This would make it very difficult to target a specific gene to edit without having a wide blast radius.
[1] https://en.wikipedia.org/wiki/V(D)J_recombination