I knew someone who was responsible for delivering backups from a secure data center to a lockbox every couple of days. Unfortunately the bank was only a few blocks from the data center so I'm not sure how much physical separation that really provided. Also this particular person would have been able to do absolutely nothing about being mugged for the disks if someone actually cared. But maybe I'm a little too paranoid.
I recall once having to drop the night's deposit off from the restaurant I worked at. They were down a manager due to illness, it was on the way home, I was a figurative if no longer a literal boyscout, so the math on "shenanigans if hinkley leaves with the money" versus "shenanigans if there is no night manager in the store" apparently leaned toward me. I'm glad they trusted me but I was a nervous wreck for four blocks until that bag went into the night deposit box.
Anything that can move "precious cargo" without a human failure mode is alright in my book.