Don't have anything significant, but giving this a quick test with some of my advent of code solutions I found it to be quite a bit slower:

   time python day_2.py             

   ________________________________________________________
   Executed in   57.25 millis    fish           external
      usr time   25.02 millis   52.00 micros   24.97 millis
      sys time   25.01 millis  601.00 micros   24.41 millis


   time codon run -release day_2.py 

   ________________________________________________________
   Executed in  955.58 millis    fish           external
      usr time  923.39 millis   62.00 micros  923.33 millis
      sys time   31.76 millis  685.00 micros   31.07 millis


   time codon run -release day_8.py 

   ________________________________________________________
   Executed in  854.23 millis    fish           external
      usr time  819.11 millis   78.00 micros  819.03 millis
      sys time   34.67 millis  712.00 micros   33.96 millis

   time python day_8.py             

   ________________________________________________________
   Executed in   55.30 millis    fish           external
      usr time   22.59 millis   54.00 micros   22.54 millis
      sys time   25.86 millis  642.00 micros   25.22 millis

It wasn't a ton of work to get running, but I had to comment out some stuff that isn't available. Some notable pain points: I couldn't import code from another file in the same directory and I couldn't do zip(*my_list) because asterisk wasn't supported in that way. I would consider revisiting it if I needed a single-file program that needs to work on someone else's machine if the compilation works as easily as the examples.

We do have a benchmark suite at https://github.com/exaloop/codon/tree/develop/bench and results on a couple different architectures at https://exaloop.io/benchmarks