I spent a year using dvorak and did notice a slight comfort increase. I've since reverted to qwerty due to device inertia. Currently the biggest interface ergonomics problem I am trying to get through is using the mouse less in windows
Try Find and Run Robot. I don't know how well it's aged, I haven't used it for about 3 years now, but at the time it was the best of the free keyboard-launcher programs out there.