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ceejayoz

> How much of it was actually the lifestyle changes?

That's why the placebo group in the trial also gets the same lifestyle changes.

> This apparently works by suppressing appetite, but doesn't cocaine do the same thing?

Sure. If they were otherwise identical, that'd be a good point, but they're not.

> Constant needle marks from weekly injections might result in more social complications than anything else...

My daughter has to give herself growth hormone injections every day, and has for nearly a decade now. You don't get needle marks from these sorts of small dosage subcutaneous injection.

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> You don't get needle marks from these sorts of small dosage subcutaneous injection.

Ah, my only experience is with things like vaccines and drawing blood; those marks last around a week on me.

Yeah, it's very different; vaccinations are generally much deeper (into muscle), and drawing blood punctures a vein causing leakage into the surrounding tissue.

Daily injections can leave a little under-the-skin scarring (feels a little like cellulite) so you have to vary the site a bit, but for most folks that's the worst of it. Well worth it for these sorts of results.

> Sure. If they were otherwise identical, that'd be a good point, but they're not.

You can say the same of opium, heroin, morphine, oxycodone, fentanyl, and Naloxone. Many of which have had i ical trials done and all of which are abused and addictive.

I simply don't trust clinical trials by large pharmaceutical companies any longer.

> You can say the same of opium, heroin, morphine, oxycodone, fentanyl, and Naloxone. Many of which have had i ical trials done and all of which are abused and addictive.

Cocaine isn't a viable weight-loss drug because its downsides outweigh the benefits. The downsides of semaglutide and tirzepatide are nothing like that of cocaine, and thus the calculus works out better for them.

> You can say the same of opium, heroin, morphine, oxycodone, fentanyl, and Naloxone.

Setting aside the fact that including naloxone in that list is a bit bizarre - it counteracts the rest of the list, everyone should have some in their first aid kit - those medications have benefits that make them sometimes appropriate clinically. (Similarly, cocaine is used medically and in a very controlled fashion in rare cases, like persistent bad nosebleeds.)

You say that Naloxone is abused and addictive? That is completely wrong. Naloxone has no addictive potential and has no potential for abuse. I think you have it confused with something else.

Ref: https://www.asam.org/docs/default-source/public-policy-state...

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