Loading is probably where I would start - we can take the 40ft container maximum load(capacity+container) as 29tons, divide by 8 to give 7250 lbs.
I discovered tires have 2 load ratings, 150/149 would mean 7400lbs in single configuration, 7150lbs in double. So there is a little inefficiency in concatenated configuration.
Google easily finds me 40' 4-axle trailer. Same company provides similarly 2-axles with the wheels doubled up.
https://www.cheetahchassis.com/containerchassis/40-lightweig...
"if you want to maximize your capacity for certain applications" ..the 'why' still is not answered.
Best I can come up with is the 4-axle config creates tire scuffing (so cost), more axles = more friction = fuel cost. And worse handling.
(But cost is a good thing, if you're marking it up & charging the customer right? - not sarcasm, it's from the link)