Getting used to spacebar, backspace and enter, all of which I shifted to thumb mappings, took only a few days. You hit those keys so often you learn the muscle memory very quickly. This to me is by far the best part of the moonlander, having 4 super-accessible thumb keys and 2 semi-accessible thumb keys that I can program is a massive, massive improvement over a standard keyboard. Your thumb is completely wasted in a normal layout.
I still am far below my "normal" speed for programming, but that is because I'm trying to figure out the best custom mapping for (){}[]<>=+ and then train the muscle memory.
Overall I'm very happy with the purchase, I feel like it is much more ergonomic and with another few months of service and perfecting my layout it will hopefully end up being much faster and more convenient than a normal keyboard layout as well.