I don't know enough about it, is DoH better/different from using DNSSEC upstream servers in Pi-hole?
With DoH, or DNS-over-HTTPS, your DNS requests are traveling through the network encrypted. The first advantage is: man in the middle can't see what domain names are you trying to resolve. The second: they don't even know if the traffic they see right now is actually resolving a domain, or just browsing a website.
So DoH is a lot more private than DNSSEC. But it's fair to say it's a lot slower than standard DNS taffic (although it's not the difference a human can actually notice in most cases).