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This would have false positives for some accessibility software, I believe

True, that's why you don't want to block the pageload on this signal alone, just use it to trigger a captcha.

It's pretty awful to make people who need accessibility software go through more captchas. Those are an accessibility nightmare.

Or even non-disabled people who typically browse using the keyboard only. Please stop sending users who you find inconvenient to captchas!

With Privacy Pass they won't see more captchas, they will actually see fewer of them.