Intersting though: sucralose is just normal saccharose, but with a hydrogen substituted with chlorine. One would think it should be the least dangerous one, due to being so similar to a natural molecule.
That said, your confusion probably originated with Splenda’s “tastes like sugar ‘cause it’s made from sugar” marketing, which was ruled to be misleading.
Research enantiomers and, more generally, chirality.
The laws governing Chemistry don't align well with the human intuitive understanding of similarity.
Cyanide is a natural molecule, and rattle snake venom is made of natural molecules.