> From what I can tell it's extremely difficult to do business without having anything you do touch something based in the US. IE if you do business nearly anywhere, Uncle Sam can (almost certainly) prosecute

If you're doing business in any way that touches people from the US (which certainly FIFA does, one way or another), then it's hard.

But for the rest of us, it's not really that hard. Everything the US has, there is a alternative for that hasn't anything to do with the US, from banking to hosting to productivity tools.