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...almost no problems...

I believe Leo Laporte sits on a ball all day when doing all those podcasts and twit live shows he does ... I don't get it - how does it help your posture? Can you not sit slouched over on a ball as easy as a normal chair? Maybe I should try this ball thing!

I tried sitting on a ball but found my back muscles tire quickly. How do you avoid this?

You keep doing it till your muscles are strong enough :)

Anyways you can do it for part of the day to build up strength. You can also do some 'front bridge' exercises. Don't push yourself just sit as long as you can, then go to a chair for an hour then jump back on.

Eventually you will be very comfortable.