Generally, the better we become in introducing mitigations, the more expensive attacks become and attackers have bosses, budgets and deadlines. They will try to find other avenues to land on a target :-)
One of my favorite exploits [0] was from Project Zero where the chain began with a vulnerability in the Apple wireless stack (Broadcom? maybe, but that might be a different exploit I'm thinking of), and ended in arbitrary kernel RCE. In other words, it was "a wormable radio-proximity exploit which allows me to gain complete control over any iPhone in my vicinity."
More relevantly to your question, here's a writeup about exploiting a GPU. [1]
[0] https://googleprojectzero.blogspot.com/2020/12/an-ios-zero-c...
[1] https://googleprojectzero.blogspot.com/2020/09/attacking-qua...