I know this is a silly thing to compare but haven't we all had huge issues with security vulnerabilities involving processors guessing what's next since like 2018? [2]
I wonder if there's any general parallels between any potential information processing system and the concept that to make it go faster you can do this. I didn't read through the whole neuroscience article yet but that's definitely the first thing that came to mind.
[1] https://en.wikipedia.org/wiki/Branch_predictor
[2] https://en.wikipedia.org/wiki/Spectre_(security_vulnerabilit...