If it was possible to drive a touch interface and SPI display of that size from an MCU of that size/speed and still be responsive. I have only driven them from Pi Zeros, PocketBeagles and other much larger/faster systems, and still noticed some drag. Up to now, I've stuck to smaller displays without a touch layer for projects where I'm using the RP2040. [caveat: I am _not_ an embedded systems SWE so still figuring out where limitations are hardware vs. my knowledge]