I'd consider anything west of 6th in SOMA to be considerably sketchier than any part of the Mission.
Not sure if this list is supposed to be a guide on where to put your office in SF, or where to live. He calls out west SOMA as "most soulless area to live in SF" - well yeah, it's the financial district, you put your office there, you don't live there.
Besides, that title more rightfully belongs to the Marina district.
Meanwhile, in the last year there have been multiple assaults, robberies and a few rapes in the part of Mission that you've called safe. YMMV.
The map bears itself out: http://www.trulia.com/crime/San_Francisco,CA,SoMa/
Somewhat crime-related but non-violent - besides the BART stops general hygiene in the Mission is not bad, whereas most of the main thoroughfares of west SOMA consistent reek of shit and piss.
> "Meanwhile, in the last year there have been multiple assaults, robberies and a few rapes in the part of Mission"
... and there haven't been in SOMA?
In any case, this is all pedantics. San Francisco is overall a crime-ridden city where its monied residents waffle between pretending crime doesn't exist, and mocking people who are concerned about it.
Of course no neighborhood is crime-free, but you're blowing the danger of SOMA entirely out of proportion based on your perceptions of aesthetics.
Palo Alto prices per square foot have gone up ridiculously in the last year as well. Seems to average around $60-80+ per square foot per year. There's hardly any space in downtown PA left unless you're willing to include your arms and legs, too...
New listings show up on Craigslist everyday. Seems you get the best deals there if you can grab a sublease which is what my current company was able to do. Alternatively, another great resource for commercial space searching is: http://www.loopnet.com/
Good luck!
I would say he went over the top on describing SOMA. It is still dead.