The plasma cycle thing is odd and I have concerns about coercion. However, I think most people are critical of him because he's richer and/or fitter than they are or because he's unusual, not making a principled moral stand. They're missing out: his self-experimentation is fascinating. 90% of it is probably bullshit or only gives a tiny incremental gain, but I just think it's neat that he keeps an unhinged geocities-tier[0] page detailing why he eats hummus with un-dutched dark chocolate from low heavy metal plantations. It's even neater that it's actually working for him in some empirical sense.