Mutations? Shuffling a deck of cards doesn't "mutate" any cards in the deck, but you will also never get the same sequence twice. I think you are mixing things up a bit about how our genes work from generation to generation.
I think that must just be an opinion. It falls short of observing everything relevant to what our genes, and what we as individuals and as species are "winning" for. It might work to say such a thing on the meta scale, but it just doesnt work to say that about someone whose DNA is undoubtedly fully represented in his/her extended family, et al. For instance, my opinion of what I would call a genetic failure would be one which persists continually without ever contributing to the greater human intellect.
It's also worth noting that we have little knowledge of genes anyways, but that might fall on deaf ears.
tl;dr Someone who is a long-living nobel prize winner is IMHO, a genetic success, regardless of procreation.