What I always thought was interesting was that when you take psychedelics, despite whether it's mushrooms, LSD, or 2C-B (and what have you), you can feel this little ball of energy in your stomach (particularly noticeable when starting to come up) that persists for most of the trip.

My woo-woo theory is that there's some kind of serotonergic activity happening in the gut (which is responsible for some ~95% of the body's serotonin production) that is so profound you can physically feel it.