My first run: I deliberately buy every option that hurts alignment with the goal of killing humanity. Eventually I run out of alignment-harming stuff to buy, and everything else helps so much that around 2080 I have a human population of 14 million.

Second run ('cause I clicked the universal jump engine by accident): I deliberately hold off on AI upgrades unless I can keep alignment high. At 2080, AI is out-earning humanity but very stupid and humanity is only at 586 million.

(Also, why does the population start off so low? Do you know something that I don't?)

EDIT: I bought all the alignment upgrades on the second run. I don't entirely understand how threatening to nuke countries that research AI improves alignment when I'm already running GPT-5 on millions of GPUs