It's a fair question! I've thought about that a lot, as someone who has plotted maybe ~200 pieces of their own work (and generated plots for ~500-ish).

In person, it is very obvious that you're looking at something created by a physical pen. The lines have a glossiness to them, a slight pressure, etc. It's an artifact a printer couldn't have created.

Process-wise, it's a fun challenge too, but that's a different thing altogether.