I did on my older MacbookPro5,1. It didn't even seem like I dislodged much dust, but it made a huge difference. Now the fans don't go above 3-4000 rpm even with the cpu pegged, which is quiet. Before it would consistently spin the fan at max speed even with modest cpu use. This old beast is far quieter under load than the new MacBook Air 13" I had for a week and returned.