That said I don't think there are any features that I'm missing out on being at .Net 6.
I think there is a limited number of maintainers of the SAFE template so they might not be able to keep on the bleeding edge. But it's not that hard to update the components to the latest versions. As can be seen on this waiting pull request https://github.com/SAFE-Stack/SAFE-template/pull/564
I should also mention that when I've hit issues with packages not working on the latest .Net version I've asked in the F# slack and twice had the maintainers fix things within a day so it would run at the latest version.