Excel is a known issue for many text data files. My least favorite Excel-ism is when it changes the names of genes to dates. Many genes recently changed names to avoid Excel-related issues. As an example: OCT4 became POU5F1, and SEPT1 became SEPTIN1. Otherwise, if you're looking at gene related data, you'd have to be very careful when looking at gene names that you didn't accidentally save the file with a few "dates" as opposed to gene names. (Which is even more confusing when you realize that dates are stored as integers in Excel).
https://sites.google.com/view/ryzvonusef/process
Wasted a week's worth of effort, but I learnt a valuable lesson.
Unicode encoding or rather anything non-ASCII is also prone to cause trouble. The automatic conversion of quoted(!) digit strings to numbers can be worked around by appending a tab character. Line breaks within a cell are a big headache, however, and I believe the U+2028 code point can still not be used instead.