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As of iOS 5 you can activate it over the air (WiFi or 3G) and optionally use iCloud for syncing your stuff instead of iTunes.

I'm under the impression that iOS5 introduced no-sync-required activation.

It actually doesn't need to be activated on a computer anymore. iOS 5+ allows the user to activate and start using their device without ever connecting it to a computer, and updates are also over the air.