Commercially-available sport drones fly at over 200 MPH, which is more than fast enough to overcome any human's reaction time, are too small and fly too low to detect via radar, are more agile and maneuverable than any plane or missile ever designed. Their biggest problem is that they are trivially jammable (which will be overcome via autonomy) and operational range (which is doubled for suicide drones).
Drones are about to change operational doctrine in all areas in the same way that aircraft carriers obsoleted battleships. Any military that fails to adapt to this new reality will be absolutely destroyed in the field. Defenses against overwhelming autonomous drone swarms are possible, but not via current missile defense platforms.