The other player in the space is Filemaker Pro - a fair bit nicer to work with than Access, although still fairly horrible from an internals point of view (I think they've moved to using proper SQL and everything since I last used it though).
I believe it started that way because our original developer didn't know anything else.
OS: Mac OS 9; DB: Filemaker Pro; templates: Lasso; webserver 4D WebSTAR.
This was in 2011.