Kagi makes it easy to essentially delist entire domains. So nice for when you find a content farm or for sites like pinterest. They even provide a list of the most blocked domains: https://kagi.com/stats (Click "Domain Insights")
Trust the search engine to do the signal/noise calculations for you. You are no longer on Google. Kagi is your agent, not your adversary.
Only sites I block on my Kagi are sites that outright trick or lie to the user; keyword content farms, pinterest, and StackOverflow cloners
I found it through Libredirect which is the same idea but for more sites, but some of the alternative sites don't work as well in my experience.