I have had serious hand pain in the past, and actually needed my wife to button the collars of shirts.

I did two things to get rid of the pain. First, I got an Advantage Kenesis keyboard, and a trackball mouse. I only use the mouse with my left hand (I am right-handed) and never touch a regular mouse. After several weeks, the hand pain completely subsided.

If you have even a minor amount of hand, wrist, forearm, or even shoulder pain, figure out what is causing it, whether it is keyboard, posture, table height and address it promptly.