Django with HTMX + Alpine on the frontend. Deployed as Docker container on a cheap VPS. It's boring, time tested but by Jove, does it get the job done fast.
I'm building a B2B2C marketplace in my free time and I'm blown away by the practicality of this stack. Due to longevity of Django, every problem I encounter is just a search away. DRF makes it dead simple to add REST APIs. The Admin panel is a golden cherry on top.