If it's a peer in a more professional setting, simply calling them out generally makes you less a target, especially if calling out their behaviour is done in a group setting. It comes down to the old "stand up for yourself" rule we've all heard. Also, calm confidence tends to work with adults too.

If the bullying is coming from above, time to move on. I have zero patience for it, and there's likely no stopping them.

Also, I'm not suggesting you take them outside, although I know a couple guys who've been through fights between coworkers in their workplaces. Grown men (in their 30s) sure can take a long time to grow.