Really surprising stuff (to me). I'm coming from the prior that large amounts of protein ingestion in one sitting are "wasted" and do not contribute much above a certain moderate amount. This is obviously only a single study, but it at least opened me up more to the possibility that this is wrong.

Some important limitations as listed in the paper:

- Study only assessed a short-term assessment window (~12 hr), and the researchers speculate that metabolic changes over time might skew these results:

"it is possible that the metabolic response to protein ingestion is modified over time. For example, it could be speculated that amino acid oxidation may increase in response to frequent, prolonged epi- sodes of hyperaminoacidemia or that large postprandial protein gains are compensated for by upregulation of amino acid oxida- tion in a subsequent fasted state"

- Study was with healthy young men after a bout of whole-body resistance exercise. May not extrapolate to other populations or conditions (i.e. at rest).

- Other study "limitations" point out that they were conservative in their conclusions, and the results of eating large amounts of protein at one time may be even stronger than stated in the paper.

Still, very interesting stuff.