I made a very, very simple game in Godot 4 with my friend this fall. To build for the web target, I ported our C# to GDScript, and it wasn't so bad. The resulting webstuff was 50MB without audio.
I ported it again to JS, and it's 50KB without audio. Maybe 150K with audio. About the size of two favicons.
Yes, the game is very very simple ( https://rezmason.net/fluid , still refining it), but the difference between 50K and 50MB is still significant.
If we had used some kind of Python to WASM toolchain, I don't know what size the project would be, but probably more than 50MB. With C# in the mix, and mono, or whatever, it would be even larger.
One of the reasons we explored Godot this year was to try other ways of producing things. GDScript helps maintain Godot's distinction from its competitors, and I'll reach for it whenever I need to make #ThatKindOfThing.