After that experience, I believe that for most people the benefits do not outweigh the risks until the drug is better studied clinically. The exceptions would be those who stand to experience exceptional quality of life improvements from a treatment-resistant depression breakthrough or cluster headache treatments (which AIUI are already pretty clinically established).
That said, I am probably too curious about life and novel experiences to have ever heeded this kind of advice if it meant not satisfying my curiosity at least once. So if you’re dying of curiosity I get how it might be worth it anyway.