What are the boundary conditions here? I'm a young developer (23) who's made over half a million USD$ from web apps while in school - would many companies be interested in hiring even with programming languages I have little to no experience with?
What is a big deal is being smart and motivated and knowing a lot about at least something useful. Everything else is gravy.
Hiring highly skilled programmers that know exactly the technologies they need is what many companies aim for when hiring, and never accomplish. They're wrong. Even Google has problems finding (and hiring) those. That's why I said it was a mistake.
So, I would expect that you can find these jobs. And the companies that are willing to hire you might also be the ones you want to work at. But some HR departments will turn you down, and some people (like the original poster) may turn you down because it's a risk. (I can't blame them - hiring the wrong person is a bad mistake, too - but they shouldn't complain it's hard to find good people.)