Not really. HTTP3 has little benefit (if any) when talking to a backend server, plus browsers only support QUIC with TLS and you probably don't want to waste CPU cycles terminating TLS on an application server and leave it load balancer (that isn't written in nodejs and supports HTTP3)

Best opportunity to contribute to a new NPM package for QUIC/HTTP3

Node.js shouldn't be used in the first place, just like any server-side JS. But more importantly, put your hacky language-specific servers behind a webserver like nginx.