I would love to see a rethinking of desktop hardware. GPU's are huge. They used to be dinky little add-on cards ... but at this point we almost need to have a dedicated mainboard for them.

Imagine this - instead of a motherboard mounted to the back of the case, it is mounted in the center. Behind it would be another motherboard, with a socket for a GPU and ram slots for memory. Kinda like a right/left brain connected with a high-speed interconnect. You open the left side of the case to access CPU and its memory, you open the right side of the case to access the GPU and its memory.

You would be able to upgrade your GPU chip independently of everything else. It wouldn't be mounted sideways in a PCI slot where additional brackets and support arms are needed. You could upgrade the RAM independently. Cooler, etc.