Autodesk's CAD stuff started life in the early 80s and needed to do plenty of trailblazing on fundamental concept of CAD user interface. They have a well-established client base that rely on intricate details of the interface. By its very nature their product is aimed at experts well educated in their domain.

Meanwhile, companies that burn most effort into "design systems" seem to be heavily B2C, and mostly concerned about getting their colors to pop, fonts to be fancy, and buttons to be rounded. (Or old ancients like IBM that are just so big that they probably are among the few exceptions to the rule and actually need a design system![1])

Not a great comparison.

[1]: Love me some slashed or dotted-0 fonts. Thank you IBM for popularizing that.

I'm not sure, is Autodesk a good answer? Wouldn't they be in the business of design and perhaps not a standard company that shouldn't do custom? Maybe I misunderstood the point though!