I own a Model S Plaid, and the horn button’s location on the yoke can generally only be reached by the driver’s right hand. Even more dangerous, its position in space changes dramatically any time you are in the middle of a turn. The horn button is not easy to press in an emergency.
Same story with the turn signals.
If you are in the middle of a turn and you have rotated the yoke 180-degrees, your turn signal buttons are now upside-down, and on the other side of the yoke. I have owned my car for a year and a half, and there are still times when I have to look at the yoke mid-turn to figure out which turn signal button is which.
So stupid.