You can change something, like how an engineering team works and how an organisation does DevOps and other things that management doesn’t really know anything about and trust their employees on. But moving an organisation into something like team topologies which is a more modern expansion on Conway, is virtually impossible from the bottom up in my experience. Change management in general is very hard both directions, but it’s much harder going upwards because going upwards means you don’t really have the support of management above you. Maybe they’ll humour you but to make an actual impact you’re going to need them onboard. You’ll even have to reach pretty far up top if you want to inflict lasting culture changes as things carried by a single (or few) managers often dies with them.
My career has sort of put me in a role where I help non-tech startups transition from that to medium or enterprise size. I solely focus on the tech journey though, as I know I won’t have too much impact on culture or work processes on the grander scale. Often this leads to a semi-team topologies approach as the tech teams divide systems into independent business related services, but as a whole I don’t expect any changes to reach outside of the development departments.