He set out with 170 men and 4 ships. 55 men and 2 ships returned. And that was not particularly remarkable - scurvy, inclement weather, rogue waves, supplies going bad, and countless other issues meant death at sea was a regular part of traveling at sea. Magellan is another one. We all learn in school that he was the first man to cross the globe. What we don't necessarily learn is that he didn't survive the voyage. He set out with 5 ships and 270 men - 18 men, not including Magellan, and 1 ship returned.
Exploration and ultimately colonization has never been something for those unwilling to risk it all, and it may very likely never be. The entire point of such things is that you're setting out to do and discover what has not been done, and what has not been discovered. In this context it's essentially impossible to have any assurance of safety.