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What actual use case do you have that CPython's GIL is affecting in any serious way? And if you do have a real case which somehow requires the removal of the GIL, why don't you just use Jython, which has no GIL and recently released an implementation of Python 2.7?

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Um, pretty much all parallelizable CPU number crunching (data mining algorithms, computer vision etc.) which aren't covered in C code. Those are especially problematic, since they're usually coupled with numpy and simillar libraries not supported on other Python implementations - including Jython.

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