Choplifter, not to be confused with Rescue Raiders[1,2], except in my memory, along with its cheat code: zippybobbypin (turns out it was actually zippy or bobbypin depending upon which cracked copy you had)[3].
Speaking of games which load fully into memory, there was a peripheral card called the Wildcard[4] which would snapshot memory to disk, making it trivial to make "backup" copies of such games. A handful of in-memory games would thus check periodically that the original disk was still present.
[1]: https://en.wikipedia.org/wiki/Rescue_Raiders
[2]: https://www.youtube.com/watch?v=F8_XsRYTO-0
[3]: https://groups.google.com/g/comp.emulators.apple2/c/JwoKZKYQ...