Hacker News Reader

Comment by xyst | Hacker News Reader

What’s the consensus on Ozempic/Wegovy/Semaglutide in the long term?

Is this something you have to take forever otherwise risk rebound due to non-suppression of desire for “sweet, savory, and salty” foods?

View on HN

The consensus from what I have heard is that it helps you while you're taking it. Most people simply regain the weight if they stop taking, albeit at a lower rate. However, there is something to be said for the fortitude required to stay at a healthy weight, versus to reach a healthy weight, especially when your habits have been put on pause for a while. It's likely easier to break it long-term if you take the drug for a period of time first.

> What’s the consensus on Ozempic/Wegovy/Semaglutide in the long term? Is this something you have to take forever otherwise risk rebound

Yes, although it’s not exactly a consensus it was indicated in the original studies. This is a class of medication for treating chronic illness it is not intended as a short term intervention.

Yes. You have to take it for the rest of your life, pretty common with drugs to treat chronic illnesses.

> chronic illnesses

Is the chronic illness here a very high appetite and being hungry all the time? What exactly accounts for some people overeating and others not?

(Genuine question, I'm trying to learn more about this area.)

Yes to both. Also, this might vary, but hunger used to hurt a lot to me. The thing that helped was going on a 5 day fast (prepared, with a doctor approbation) and especially going through the pain on the 2nd day, which hurt more than when I broke my ankle, probably the worst pain I remember.

Nowadays, being hungry doesn't hurt as much, so I can easily let myself go hungry,and I'm at a healthy BMI.

The chronic illness is obesity. GLP-1 drugs are being used to treat obesity.

Reply on news.ycombinator.com