> Despite similar average weekly energy intake (~9000 kcals/week) and physical activity energy expenditure (~350kcals/day; p = 0.260) during the intervention, participants following the IF-P regimen lost significantly more body weight (−8.81 ± 0.71% vs.−5.40 ± 0.67%; p = 0.003; Fig. 1c; Supplementary Data 1) and total, abdominal, and visceral fat mass and increased fat-free mass percentage (~2×; p ≤ 0.030), as previously reported.

Interesting. Calorie in, calorie out getting btfo'd lol. I'm guessing the gut microbiome change has a lot to do with this, not just the fact that the body is forced to use more protein.

> The IF-P regimen consisted of 35% carbohydrate, 30% fat, and 35% protein for five to six days per week and a weekly extended modified fasting period (36–60 h) consisting of 350–550 kcals per day using randomization, as detailed previously. In comparison, the CR regimen consisted of 41% carbohydrate, 38% fat, and 21% protein in accordance with current US dietary recommendations

Wonder if the fat loss is due to intermittent fasting or the higher protein. Guessing a combination.

Also should note that the IF-P diet has "significantly" less sugar and more dietary fiber than the CR diet, which would also contribute to the gut microbiome change and the fat loss etc.